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NAD+ 1000MG

$195.00Price
Excluding Sales Tax
Core cellular coenzyme for redox, DNA repair and sirtuin/PARP signaling. Potential benefits of augmenting NAD+ pools include supporting metabolic health, stress resistance and aspects of healthy aging. Human supplementation studies show mixed, mostly short‑term biochemical gains; clinical outcome benefits remain uncertain.
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  • NAD+- Research & Chemical Profile

    Description

     

    NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a ubiquitous redox coenzyme present in all living cells. Beyond its classical role as an electron carrier in energy metabolism (glycolysis, TCA cycle, oxidative phosphorylation), NAD+ serves as an essential co‑substrate for NAD‑dependent enzymes including sirtuins, poly(ADP‑ribose) polymerases (PARPs), and CD38/CD157 ecto‑enzymes. Cellular NAD+ pools influence DNA repair, chromatin state, mitochondrial function, stress responses, circadian regulation, immune signaling, and aging biology.

     

    Chemical Structure / Identifiers

    Property

    Detail

    Preferred Name

    β‑Nicotinamide adenine dinucleotide (oxidized form); NAD+

    Synonyms

    Diphosphopyridine nucleotide (DPN); Coenzyme I; Nadide

    Molecular Formula (anhydrous)

    C21H27N7O14P2

    Molecular Weight (anhydrous)

    ≈ 663.43 g/mol

    CAS Number

    53‑84‑9

    PubChem CID

    925 (β‑NAD); 5892/5893 (Nadide entries)

     

    Primary Research Focus

    • Cellular energy and redox: electron carrier in dehydrogenase reactions; central to ATP production.
    • Sirtuin biology: co‑substrate for class III histone deacetylases regulating metabolism, stress resistance, and longevity pathways.
    • DNA repair/chromatin: PARP‑dependent ADP‑ribosylation uses NAD+ to coordinate DNA damage responses and chromatin remodeling.
    • Immune and inflammatory signaling: CD38‑mediated NAD+ turnover modulates calcium signaling and immune cell function.
    • Aging and metabolic health: NAD+ declines with age; NAD+ augmentation via precursors (e.g., NR, NMN) is under investigation for cardiometabolic and neuroprotective effects.

     

    Safety / Limitations

    • Research Use Only in this context; NAD+ biology is well established, but many supplementation claims remain under active study.
    • Evidence for NAD+ augmentation in humans is mixed and often short‑term; long‑term efficacy and safety data are limited and context‑dependent.
    • Some interventions (e.g., high‑dose precursors) can alter methyl‑donor balance or interact with existing conditions/medications; clinical oversight is advised in experimental contexts.

     

    Key Publications / References

    PubChem Compound Summary: β‑Nicotinamide adenine dinucleotide (CID 925). https://pubchem.ncbi.nlm.nih.gov/compound/925

    Katsyuba & Auwerx (2020). NAD+ homeostasis in health and disease. Nat Rev Mol Cell Biol. https://europepmc.org/article/med/32694684

    Covarrubias et al. (2021). NAD+ metabolism in cellular processes during aging. Nat Rev Mol Cell Biol. https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/

    Kane & Sinclair (2018). Sirtuins and NAD+ in development and treatment of cardiovascular/metabolic disease. Front Pharmacol. https://pmc.ncbi.nlm.nih.gov/articles/PMC6206880/

    Conlon (2021). The role of NAD+ in regenerative medicine. Rejuvenation Res. https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/

    Cantó et al. (2009). AMPK regulates energy expenditure by modulating NAD+ metabolism. PNAS. https://europepmc.org/article/med/19262508

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