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Kisspeptin 10MG

$92.00Price
Excluding Sales Tax
Endogenous decapeptide fragment that stimulates GnRH and activates the HPG axis. Potential benefits include supporting diagnostics and research in fertility, hypogonadism, and libido. Early human studies show acute LH/testosterone rises. Longer‑term therapeutic effects are still under study.
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  • Kisspeptin-10 (KP-10) Research & Chemical Profile

    Description

    Kisspeptin-10 (KP-10) is a decapeptide fragment of the KISS1 gene product that acts as an endogenous ligand at the kisspeptin receptor (KISS1R/GPR54). KP-10 potently stimulates hypothalamic gonadotropin-releasing hormone (GnRH) secretion, thereby activating the hypothalamic–pituitary–gonadal (HPG) axis. The peptide has been investigated for roles in reproductive endocrinology, puberty initiation, fertility modulation, and tumor biology.

     

    Chemical Structure / Identifiers

    Property

    Detail

    Sequence

    H–Tyr–Asn–Trp–Asn–Ser–Phe–Gly–Leu–Arg–Fhe–NH₂ (KP-10)

    Molecular Formula

    C63H83N17O14 (PubChem CID 25240297)

    CAS Number

    374675-21-5 (IUPHAR/British Pharmacological Society Guide to Pharmacology)

    PubChem CID

    25240297 (Kisspeptin-10)

    Synonyms

    KP-10; Kisspeptin (45–54); Metastin 45–54; Kisspeptin decapeptide

     

    Primary Research Focus

    • Reproductive axis activation: KP-10 stimulates GnRH release, increasing LH and testosterone secretion in humans and animal models.
    • Puberty and fertility research: central in timing of puberty and regulation of ovulation/spermatogenesis.
    • Oncology/angiogenesis: KP-10 has been reported to inhibit VEGF-driven angiogenesis and tumor growth in preclinical models.
    • Neuroendocrine signaling: integrates with neurokinin B and dynorphin neurons in the arcuate nucleus to regulate GnRH pulsatility.

     

    Safety / Limitations

    • Human studies show acute endocrine responses, but long-term safety/efficacy data are limited.
    • Effects can be dose- and route-dependent; tachyphylaxis has been described with continuous infusion.
    • Research Use Only; not approved for diagnosis, treatment, or prevention of disease.

     

    Key Publications / References

    PubChem Compound Summary: Kisspeptin-10 (CID 25240297). https://pubchem.ncbi.nlm.nih.gov/compound/25240297

    IUPHAR/BPS Guide to Pharmacology: kisspeptin-10 ligand page (CAS 374675-21-5; synonyms). https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1283

    Comprehensive review of kisspeptin in reproduction: Clarke et al., 2015. https://pmc.ncbi.nlm.nih.gov/articles/PMC4508256/

    Clinical physiology: Kisspeptin-10 stimulates LH/testosterone in men, George et al., 2011. https://pmc.ncbi.nlm.nih.gov/articles/PMC3380939/

    Mechanistic review: Kisspeptin–GnRH pathway and HPG control, Skorupskaite et al., 2014. https://pmc.ncbi.nlm.nih.gov/articles/PMC4063702/

    Additional overview: Frontiers in Endocrinology 2022 review on kisspeptin–KISS1R signaling. https://www.frontiersin.org/articles/10.3389/fendo.2022.925206/full

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